Investigation of differentially expressed genes in CKD model mice kidney

In chronic kidney disease (CKD) state, various changes in gene expression in kidneys are occurring, reflecting accumulation of uremic toxins, local inflammation, increased oxidative stress, and up-regulation of pro-fibrotic signals. However, little studies have been conducted for comprehensive evaluation of transcriptomic changes in CKD kidneys. Identification of key signals in CKD may lead to the elucidation of the mechanism of CKD progression and the development of therapeutic methods.

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