Description
Hematopoietic stem cells (HSCs) are a specialized group of cells with the ability to self-renew and differentiate into distinct lineages of the entire hematopoietic system throughout lifetime. The maintenance of a quiescent state is essential for sustaining the normal function of HSCs. Many regulatory factors involved in HSC quiescence maintenance have been found. However the role steroid receptor coactivator 3 (SRC-3) in the regulation of HSC maintenance remains unexplored.