Search for recessive retinitis pigmentosa genes using RNA expression analysis in lymphoblasts

Recessive retinitis pigmentosa (RP) is often caused by nonsense mutations that lead to low mRNA levels as a result of nonsense-mediated decay. Some RP genes are expressed at detectable levels in leukocytes as well as in the retina. We designed a microarray-based method to find recessive RP genes based on low lymphoblast mRNA expression levels

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Hartong DT, Dange M, McGee TL, Berson EL, Dryja TP, Colman RF