Identifying Significant Temporal Variation in Time Course Microarray Data Without Replicates

An important component of time course microarray studies is the identification of genes that demonstrate significant time-dependent variation in their expression levels. Until recently available methods for performing such significance tests required replicates of individual time points. This paper describes a replicate-free method that was developed as part of a study of the estrous cycle in the rat mammary gland in which no replicate data was collected.

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Billups SC, Neville MC, Rudolph M, Porter W, Schedin P