Expression data from ileum samples from FADD IEC-KO (intestinal epithelial cell-knock out) and CASP8 IEC-KO mice in combination with different genetic mutations (Zbp1 -/-, Mlkl -/-, Ripk3 IEC-KO)

GSE137280

Mus musculus

45 Downloadable Samples

Affymetrix Mouse Clariom S Array (clariomsmouse)

Submitter Supplied Information

Description

FADD-IEC KO and CASP8 IEC-KO mice spontaneously develop chronic ileitis charcterized by inflammatory gene expression. We characterized the role of MLKL, RIPK3, ZBP1, in the upregulation of inlflammatory genes in these mice.

PubMed ID

32362323

Publication Title

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells.

Total Samples

Submitter’s Institution

University of Cologne

Authors

Schwarzer R, Jiao H, Wachsmuth L, Tresch A, Pasparakis M

Source Repository

Gene Expression Omnibus (GEO)

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