Hypoxia and dimethyloxalylglycine (DMOG) downregulates tryptophan-2,3-dioxygenase (TDO2) expression in GBM cells

GSE138535

Homo sapiens

16 Downloadable Samples

Affymetrix Human Gene 2.0 ST Array (hugene20st)

Submitter Supplied Information

Description

The tryptophan degrading enzyme TDO2 is downregulated upon HIF1alpha stabilization by exposure to both hypoxia as well as chemical hypoxia mimetics such as DMOG in glioblastoma cell line A172.

PubMed ID

31866995

Publication Title

Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma.

Total Samples

Submitter’s Institution

DKFZ

Authors

Mohapatra SR, Sadik A, Tykocinski LO, Dietze J, Poschet G, Heiland I, Opitz CA

Source Repository

Gene Expression Omnibus (GEO)

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