Expression data in HTETOP cells following tetracycline or dexrazoxane treatment

HTETOP cells, derived from the human fibrosarcoma cell line HT1080, express human topoisomearse II (TOP2A) exclusively from a tetracycline (TET)-regulated transgene, we used HTETOP cells to differentiate between TOP2A-dependent and independent apoptotic effects of doxorubicin and dexrazoxane.

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Yan T, Deng S, Metzger A, Gödtel-Armbrust U, Porter AC, Wojnowski L