GRE specific DNA-binding polyamide effect on dexamethasone-stimulated lung adenocarcinoma cell line

GSE17307

Homo sapiens

14 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

Analysis of dexamethasone-stimulated A549 lung adenocarcinoma epithelial cells treated with a glucocorticoid response (GR) element (GRE) specific DNA binding polyamide. Polyamide designed to target the sequence 5'-WGWWCW-3' and disrupt GR-mediated gene expression. Effects of the GR antagonist mifepristone also examined.

PubMed ID

19805343

Publication Title

Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression.

Total Samples

Submitter’s Institution

California Institute of Technology

Authors

Muzikar KA, Nickols NG, Dervan PB

Source Repository

Gene Expression Omnibus (GEO)

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