Human colorectal cancer cell lines treated with several inhibitors of PI3Kinase AKT signaling pathway

GSE18005

Homo sapiens

15 Downloadable Samples

Affymetrix Human Genome U133A Array (hgu133a)

Submitter Supplied Information

Description

Signal transduction processes mediated by phosphatidyl inositol phosphates affect a broad range of cellular processes such as cell cycle progression, migration and cell survival. The protein kinase AKT is one of the major effectors in this signaling network. Chronic AKT activation contributes to oncogenic transformation and tumor development. Therefore, new small drugs were designed to block AKT activity for cancer treatment.

PubMed ID

20546605

Publication Title

Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbations.

Total Samples

Submitter’s Institution

Charit - Universittsmedizin Berlin

Authors

Krech T, Thiede M, Hilgenberg E, Schäfer R, Jürchott K

Source Repository

Gene Expression Omnibus (GEO)

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