Expression data from tamoxifen treated and control injection treated Tg(MHC-MerCreMer) and wild type mus musculus.

GSE19344

Mus musculus

21 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

-myosin heavy chain promoter controlled MerCreMer expression enables conditional, cardiomyocyte specific and tamoxifen dependent gene inactivation of floxed genes. Administration of tamoxifen has been linked to development of acute and transient cardiomyopathy. The mechanism for this is unknown.

PubMed ID

20802136

Publication Title

Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) mice.

Total Samples

Submitter’s Institution

University of Oslo

Authors

Hougen K, Aronsen JM, Stokke MK, Enger U, Nygard S, Andersson KB, Christensen G, Sejersted OM, Sjaastad I

Source Repository

Gene Expression Omnibus (GEO)

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