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Accession IconGSE21016

Genome-wide analysis of gene expression profiles in ITNK

Organism Icon Mus musculus
Sample Icon 12 Downloadable Samples
Technology Badge IconIllumina MouseWG-6 v2.0 expression beadchip

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Description
Analysis of gene expression profiles in Induced T-to-Natural Killer (ITNK), compared to DN3 parental T cells and IL-2-expanded NK cells (LAK). The hypothesis tested in the present study was that gene expression profiles of ITNK that were derived from DN3 T cells after deletion of Bcl11b were more similar to LAK, rather than DN3 T cells. Results provide important information of the ITNKs, such as canditate genes regulated by Bcl11b, up-regulated important genes expressed in NK cells, and down-regulated T cell genes.
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