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Accession IconGSE21891

Expression data from insulin-treated human primary fibroblasts and effects of U0126 on insulin-induced gene expression

Organism Icon Homo sapiens
Sample Icon 128 Downloadable Samples
Technology Badge Icon Affymetrix Human Genome U133A 2.0 Array (hgu133a2)

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We carried out a high throughput analysis of insulin-induced kinase signaling pathways in primary fibroblasts from 35 unrelated individuals. We found that extensive individual variation exists in induction of various signaling pathways. ERK signaling displayed the greatest variation, which led to extensive variation in expression of downstream target genes.
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