Transcriptomes of monocyte-derived DCs stimulated with various compounds

GSE23371

Homo sapiens

11 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

Little is known about the early transcriptional events in innate immune signaling in immature and tolerogenic monocyte-derived dendritic cells (DCs), the professional antigen-presenting cells of our immune system. TLR ligands usually induce a proinflammatory transcriptional response, whereas IL10 and/or dexamethasone induce a more tolerogenic phenotype.

PubMed ID

21708028

Publication Title

MicroRNA genes preferentially expressed in dendritic cells contain sites for conserved transcription factor binding motifs in their promoters.

Total Samples

Submitter’s Institution

Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Center Nijmegen

Authors

Jansen BJ, Sama IE, Eleveld-Trancikova D, van Hout-Kuijer MA, Jansen JH, Huynen MA, Adema GJ

Source Repository

Gene Expression Omnibus (GEO)

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