Global changes of expression patterns of vaccinia virus infected lungs of C57BL/6 mice.

Vaccinia virus infection of mouse lungs produces a focal infection within the lung remaining at the large bronchi throughout the course of infection. Animals die of respiratory failure with little edema and few infiltrating immune cells. It is well established that poxviruses control the host immune system by encoding multiple host defense pathway antagonists.

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Rice AD, Turner PC, Embury JE, Moldawer LL, Baker HV, Moyer RW