Genomic expression study of regenerated endothelial cells in high cholesterol-fed and fish oil-rich groups

Experiments on primary cultures of native and regenerated endothelial cells demonstrated genomic changes in the latter related to vasomotor control, coagulation, oxidative stress, lipid metabolism and extracellular matrix. However, the genomic changes caused by the combination of either hyperlipidemia or supplementation with polyunsaturated fatty acids and endothelial regeneration are unknown.The present experiments were designed to test the hypothesis that endothelial regeneration process is affected differentially at the genomic level by the exposure to either high cholesterol or PUFA-rich diet in vivo.

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Lee MY, Cai Y, Wang Y, Liao SY, Liu Y, Zhang Y, Bai B, Tse HF, Vanhoutte PM