Fetal Rat Testis mRNA Expression after 50 mg/kg Dibutyl Phthalate Exposure

High dose level dibutyl phthalate (DBP) exposure of fetal rat testes in vivo inhibits testosterone production (i.e. endocrine disruption). Here, fetal testis mRNA levels were profiled following exposure to a DBP dose level that did not significantly reduce testosterone levels. The goal was to identify the constellation of gene expression changes that do not correlate with endocrine disruption.

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Johnson KJ, McDowell EN, Viereck MP, Xia JQ