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Accession IconGSE28786

siRNA off-target effects can be reduced at concentrations that match their individual potency

Organism Icon Homo sapiens
Sample Icon 53 Downloadable Samples
Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

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Description
This study demonstrates that siRNA off-targets (e.g. 3'UTR off-targets), can be significantly reduced when cells are treated with a relatively low dose of siRNA (e.g. 1nM) that is sufficient to effectively silence the intended target.
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