Expression data from Ad--catenin-GFP or Ad-GFP infected cardiomyocytes

The Wnt pathway is a key regulator of embryonic development, cell growth, differentiation, polarity formation, neural development, carcinogenesis, and stem cell self-renewal, and deregulation of the Wnt signalling is associated with many human disease. The central player in the Wnt pathway is -catenin, A recent study has shown that -catenin/Tcf/Lef signaling pathway is an essential growth-regulatory pathway in cardiomyocytes.

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