Gene expression comparison of liver tissue from C57BL/6J and KK/HIJ mice

A QTL intercross was performed bewteen C57BL/6J and KK/HIL for albuminurea, asthma and cardiovascular related phenotypes. Several QTL were identified for most phenotypes. We performed microarray analysis from liver samples to identify genes differentially expressed between the parental strains. The results helped us narrow down the QTL and identify the candidate genes based on differential expression between the parental strains.

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Leduc MS, Savage HS, Stearns TM, Cario CL, Walsh KA, Paigen B, Berndt A