The ERRalpha metabolic nuclear receptor controls growth of colon cancer cells

Estrogen-Related Receptor alpha (ERR) is a nuclear receptor that acts principally as a regulator of metabolism processes particularly in tissues subjected to high-energy demand. Besides its implication in energy metabolism and mitochondrial biogenesis, ERR was recently associated with tumorigenesis. Notably, increased expression of ERR was noted in different cancerous tissues as breast, ovary and colon. However, supplemental studies are required to better understand the role of ERR in colon carcinoma.

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Bernatchez G, Giroux V, Lassalle T, Carpentier AC, Rivard N, Carrier JC