Gene expression profiling of the cell death induced by heat stress in DNA-PK-knockdown human cervical carcinoma HeLa cells

The objective of the present study is to investigate the role of DNA-PK inhibition in cell death induced by heat stress (44C, 60 min). Comparative gene expression analysis was performed with mock cells, negative control siRNA-treated cells and DNA-PK siRNA-treated cells. The expression of DNA-PK was confirmed by Western blotting. Gene expression was analyzed using GeneChip oligonucleotide microarrays and computational gene expression analysis tools.

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Okazawa S, Furusawa Y, Kariya A, Hassan MA, Arai M, Hayashi R, Tabuchi Y, Kondo T, Tobe K