github link
Accession IconGSE4026

A Distinct QscR Regulon in the Pseudomonas aeruginosa Quorum Sensing Circuit

Organism Icon Pseudomonas aeruginosa
Sample Icon 29 Downloadable Samples
Technology Badge Icon Affymetrix Pseudomonas aeruginosa Array (paeg1a)

Submitter Supplied Information

Description
To better understand the role of QscR in P. aeruginosa gene regulation and to better understand the relationship between QscR, LasR and RhlR control of gene expression we used transcription profiling to identify a QscR-dependent regulon. Our analysis revealed that QscR activates some genes and represses others. Some of the repressed genes are not regulated by the LasR-I or RhlR-I systems while others are. The LasI-generated 3-oxododecanoyl-homoserine lactone serves as a signal molecule for QscR. Thus QscR appears to be an integral component of the P. aeruginosa quorum sensing circuitry. QscR uses the LasI-generated acyl-homoserine lactone signal and controls a specific regulon that overlaps with the already overlapping LasR and RhlR-dependent regulons.
PubMed ID
Total Samples
30
Submitter’s Institution

Samples

Show of 0 Total Samples
Filter
Add/Remove
Accession Code
Title
Processing Information
Additional Metadata
No rows found
Loading...