GSE44907Transcription profiling by array of HC11 mammary epithelial cell strains stably expressing different variants of the transcriptional regulator megakaryoblastic leukemia-1 (Mkl1)
Mus musculus
9 Downloadable Samples
Affymetrix Mouse Gene 1.0 ST Array (mogene10st)Submitter Supplied Information
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We have previously shown that HC11 mammary epithelial cells react strongly to the overexpression of megakaryoblastic leukemia-1 (Mkl1) with induction of tenascin-C expression. The present study was designed to find genes co-regulated with tenascin-C by Mkl1 in a SAP domain-dependent manner and without the involvement of serum response factor (SRF). For this purpose, we compared the transcriptomes of three stable HC11 cell strains that either overexpress full length Mkl1-RFP (HC11-FL), Mkl1-RFP with a mutated SRF-interaction site (HC11-mutB1) or Mkl1-RFP with a deletion of the SAP domain (HC11-SAP).
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HC11-FL_rep1
mammary epithelial hc 11 cells originating from mid-pregnancy balb/c mice (danielson et al., 1984; ball et al., 1988)
HC11-mutB1_rep3
mammary epithelial hc 11 cells originating from mid-pregnancy balb/c mice (danielson et al., 1984; ball et al., 1988)
HC11-mutB1_rep1
mammary epithelial hc 11 cells originating from mid-pregnancy balb/c mice (danielson et al., 1984; ball et al., 1988)
HC11-FL_rep3
mammary epithelial hc 11 cells originating from mid-pregnancy balb/c mice (danielson et al., 1984; ball et al., 1988)
HC11-mutB1_rep2
mammary epithelial hc 11 cells originating from mid-pregnancy balb/c mice (danielson et al., 1984; ball et al., 1988)
HC11-SAP_rep2
mammary epithelial hc 11 cells originating from mid-pregnancy balb/c mice (danielson et al., 1984; ball et al., 1988)
HC11-FL_rep2
mammary epithelial hc 11 cells originating from mid-pregnancy balb/c mice (danielson et al., 1984; ball et al., 1988)
HC11-SAP_rep1
mammary epithelial hc 11 cells originating from mid-pregnancy balb/c mice (danielson et al., 1984; ball et al., 1988)
HC11-SAP_rep3
mammary epithelial hc 11 cells originating from mid-pregnancy balb/c mice (danielson et al., 1984; ball et al., 1988)
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