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GSE50383
AR function is altered by polyglutamine expansion and by SUMO
Rattus norvegicus
18 Downloadable Samples
Affymetrix Mouse Gene 2.1 ST Array (mogene21st)
Submitter Supplied Information
Description
Expansion of a polyglutamine (polyQ) tract in the gene for the androgen receptor (AR) results in partial loss of transactivation function and causes spinobulbar muscular atrophy (SBMA). Modification of AR by small ubiquitin-like modifier (SUMO) reduces AR function in a promoter context-dependent manner.