Prevention of mammary tumor progression by silencing HoxA1 via intraductal injection of nanoparticle-formulated siRNA

GSE50813

Mus musculus

24 Downloadable Samples

Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description

Silencing HoxA1 in vivo by intraductal delivery of nanoparticle-formulated siRNA reduced mammary tumor incidence by 75% , reduced cell proliferation, and prevented loss of ER and PR expression.

PubMed ID

24382894

Publication Title

Silencing HoxA1 by intraductal injection of siRNA lipidoid nanoparticles prevents mammary tumor progression in mice.

Total Samples

Submitter’s Institution

Mayo Clinic

Authors

Brock A, Krause S, Li H, Kowalski M, Goldberg MS, Collins JJ, Ingber DE

Source Repository

Gene Expression Omnibus (GEO)

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