The transcriptomic responses of THP1 human monocyte-like cells expressing SP110b to interferon gamma stimulation

SP110b is an interferon (IFN)-induced nuclear protein and may function as a transcriptional co-activator/repressor. IFN activates monocytes/macrophages thereby mediating inflammation. However, uncontrolled activation induces monocyte/macrophage cell death, which may cause immunopathology. We have demonstrated that SP110b expression prevented IFN-mediated monocyte/macrophage cell death.

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Leu JS, Chen ML, Chang SY, Yu SL, Lin CW, Wang H, Chen WC, Chang CH, Wang JY, Lee LN, Yu CJ, Kramnik I, Yan BS