Gene expression profiles of human CD45RA+CCR7-CD8+ T cells

GSE69072

Homo sapiens

16 Downloadable Samples

Affymetrix Human Gene 1.0 ST Array (hugene10st)

Submitter Supplied Information

Description

Human CD8+ T cells are functionally heterogeneous and can be divided into distinct subsets according to CCR7 and CD45RA expression levels. Among the subsets, CCR7-CD45RA+ CD8+ T cells are considered to be terminally differentiated cells and designated as Temra. Temra show attenuated ability to proliferate and produce IFN-gamma in response to TCR stimulation, while Temra show improved function after IL-15 treatment.

PubMed ID

26857736

Publication Title

IL-15 boosts the function and migration of human terminally differentiated CD8+ T cells by inducing a unique gene signature.

Total Samples

Submitter’s Institution

Kyoto University

Authors

Setoguchi R

Source Repository

Gene Expression Omnibus (GEO)

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