eHSP70 promotes osteogenesis of hMSCs through activating ERK signaling pathway

GSE71080

Homo sapiens

2 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

Heat shock proteins are highly conserved proteins that, when produced intracellularly, protect stress exposed cells. It has been suggested that extracellular Hsp70 has both protective and deleterious effects. Our study showed eHSP70 increased the ALP activity, promoted mineralization and up-regulated osteogenesis-related markers.

PubMed ID

26608032

Publication Title

Extracellular heat shock protein 70 promotes osteogenesis of human mesenchymal stem cells through activation of the ERK signaling pathway.

Total Samples

Submitter’s Institution

Second Affiliated Hospital, School of Medicine, Zhejiang University

Authors

Chen E, Xue D, Zhang W, Lin F, Pan Z

Source Repository

Gene Expression Omnibus (GEO)

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