Hematopoietic stem cell mobilization with G-CSF (gene expression profiling)

Granulocyte-colony stimulating factor (G-CSF) is used to boost granulocyte counts in immunocompromised patients, but its effects on the immune system may be counter productive. We tested the hypothesis that G-CSF mobilized peripheral blood stem cell (PBSC) products are immunologically down regulated based on gene microarray analysis.

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Buzzeo MP, Yang J, Casella G, Reddy V