Identification of LEDGF-responsive genes in Jurkat cells

GSE7508

Homo sapiens

6 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

The LEDGF transcript from the PSIP1 gene was knocked down in Jurkat cells using RNAi technology. The resulting Jurkat-derived cell line (Jurkat-siJK2) was compared to a control cell line (wild type Jurkat) using microarray analysis. Genes identified as being modulated by LEDGF were preferential targets of HIV integration.

PubMed ID

17545577

Publication Title

HIV integration site selection: analysis by massively parallel pyrosequencing reveals association with epigenetic modifications.

Total Samples

Submitter’s Institution

University of Pennsylvania School of Medicine

Authors

Wang GP, Ciuffi A, Leipzig J, Berry CC, Bushman FD

Source Repository

Gene Expression Omnibus (GEO)

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