Notch pathway is overexpressed and is a therapeutic target in clear cell renal cancer

We generated a list of Notch target genes in vivo by determining differentially expressed genes in tubules obtained from Pax8rtTA TREICNotch1 mice compared to controls.

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Bhagat TD, Zou Y, Huang S, Park J, Palmer MB, Hu C, Li W, Shenoy N, Giricz O, Choudhary G, Yu Y, Ko YA, Izquierdo MC, Park AS, Vallumsetla N, Laurence R, Lopez R, Suzuki M, Pullman J, Kaner J, Gartrell B, Hakimi AA, Greally JM, Patel B, Benhadji K, Pradhan K, Verma A, Susztak K