Lymphtoxin pathway effects on thymic medullary epithelial cells

We compared gene expression profiles of lymphotoxin alpha- and lymphtoxin beta receptor-deficient thymic medullary epithelial cells with their wild-type littermates, as well as with Aire-deficient and wild-type littermates. This was done in order to determine whether there was overlap in the effects of lymphotoxin and aire.

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Venanzi ES, Gray DH, Benoist C, Mathis D