Identification of gene expression changes in RGC neurons treated with synaptogenic proteins

GSE86595

Rattus norvegicus

6 Downloadable Samples

Affymetrix Rat Genome 230 2.0 Array (rat2302)

Submitter Supplied Information

Description

Astrocyte-secreted proteins induce synapse formation between isolated retinal ganglion cell (RGC) neurons in culture. We asked whether 2 of these proteins, glypican 4 (Gpc4) or thrombospondin 1 (TSP1) induce synapse formation by regulating gene expression in RGCs.

PubMed ID

29024665

Publication Title

Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation.

Total Samples

Submitter’s Institution

Salk Institute

Authors

Farhy-Tselnicker I, van Casteren ACM, Lee A, Chang VT, Aricescu AR, Allen NJ

Source Repository

Gene Expression Omnibus (GEO)

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