Comparison of the transcriptomic profile of P. falciparum reactive polyfunctional and IFNg monofunctional human CD4 T cells

Pathogen-specific polyfunctional T cell responses have been associated with favorable clinical outcomes but it is not known whether polyfunctional T cells are distinct from monofunctional cytokine producing T cells. In this study we compared the transcriptomic profile of P. falciparum reactive polyfunctional and IFNg monofunctional CD4 T cells by microarray analysis and show that polyfunctional CD4 T cells are associated with a unique transcriptomic signature.

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Burel JG, Apte SH, Groves PL, McCarthy JS, Doolan DL