Dietary selenium levels affect selenoprotein expression and support the interferon-? and IL-6 immune response pathways in mice [Ribosome Profiling]

Mice were fed Se-deficient or Se-adequate diets for 6 weeks. Liver and lung tissue were harvested and processed for RNA-Seq, ribosome profiling, and microarray analysis. From these studies, we identified changes in mRNA levels and translation of selenoprotein genes and genes regulated by interferon-gamma. Cytokine profiles of serum indicated that interferon-gamma and IL-6 levels were increased in the Se-adequate mice relative to Se-deficient mice. Overall design: Ribosome profiling of liver tissue from mice fed Se-deficient or Se-adequate diets

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Tsuji PA, Carlson BA, Anderson CB, Seifried HE, Hatfield DL, Howard MT