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Accession IconSRP070581

Epigenetic Profiles Signify Cell Fate Plasticity in Unipotent Spermatogonial Stem and Progenitor Cells (RNA-Seq)

Organism Icon Mus musculus
Sample Icon 17 Downloadable Samples
Technology Badge IconIllumina HiSeq 1000

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Description
Mammalian spermatogonial stem cells (SSCs) spontaneously convert to multipotent adult spermatogonial-derived stem cells (MASCs) during in vitro expansion. Here, we examine the epigenetic signature of SSCs and MASCs, identifying bivalent histone H3-lysine4 and -lysine27 trimethylation at somatic gene promoters in SSCs and an ESC-like promoter chromatin state in MASCs. Overall design: Examination of gene expression in different cell types.
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17
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