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Accession IconSRP070880

Estrogen and mTORC1 dependent genes in the uterus of uterine-specific Tsc2-null mice

Organism Icon Mus musculus
Sample Icon 18 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500

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Description
To uncover genes regulated by mTORC1 and estradiol in uterine Tsc2-null LAM like cells, we performed RNAseq on uteri from 12-week old wild-type (WT) and uterine-specific Tsc2-null (KO) mice that were either untreated (intact), oopherectomized (ovx) or oopherectomized + treated with 17ß-estradiol pellets (E2) for 8 weeks. We identified genes that were both estradiol- and TSC2-mediated. Overall design: Uterine mRNA profiles of 12 week old wild type (WT) and uterine-specific Tsc2-null (KO) mice in the presence or absence of estradiol were generated using Illumina HiSeq2500
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18
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