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Accession IconSRP092280

Transcriptome analysis of tumor-specific CD8 T cells in murine solid tumors

Organism Icon Mus musculus
Sample Icon 36 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500

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Description
RNAseq analysis of CD8 T cells becoming dysfunctional in progressing tumors. The overall goal of this study was to elucidate the molecular program that mediates functional unresponsiveness in tumor-specific CD8 T cells. In comparison, we also investigated CD8 T cells differentiating to functional effector and memory T cells during an acute listeria infection. Overall design: T cells were sorted by flow cytometry and RNA-seq was performed.
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38
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