Understanding the role of PCAT92 in prostate cancer

Many lncRNA are known to be differential expressed in prostate cancer. One such lncRNA is PCAT92, which by has been shown to be over-expressed in prostate cancer samples when compared to adjacent normal tissue. PCAT92 shares its chromosomal locus with ABCC4, a genes already reported to be implicated in prostate cancer. Here we have explored the possible mechanism by which PCAT92 is playing a role in prostate cancer. Here we made LNCaP which were knockdown PCAT92 and ABCC4 independently and performed a RNA-sequencing to see the change in gene expression under both the knockdown condition.

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