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Accession IconSRP155778

Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation.

Organism Icon Mus musculus
Sample Icon 2 Downloadable Samples
Technology Badge IconNextSeq 500

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Description
This scRNA-seq experiment is an integral part of a manuscript with the above title. Our analysis of the scRNA-seq data suggests that activated CARD11 promotes immunoglobulin class-switching in germinal center B cells and generation of IgG1-secreting plasma cells. Overall design: Single-cell suspensions were prepared from spleens harvested from mice 5 days post immunization with sheep red blood cells. B cells were enriched using an immunomagnetic negative selection kit. scRNA-seq was performed using the Chromium product suite by 10x Genomics.
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