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Accession IconSRP172671

Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner

Organism Icon Homo sapiens
Sample Icon 10 Downloadable Samples
Technology Badge IconNextSeq 500

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Description
RNA-seq analysis of BJ cells overexpressing RasV12 and escaping senescence Overall design: Immortalized BJ-hTERT cells expressing an oncogenic version of Ras under the control of a doxycyclin-inducible promoter were grown for 60 days in the presence of Dox to induce oncogene-induced senescence (OIS). Three individual clones escaping senescence were isolated and were analyzed by RNA-seq.
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10
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