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accession-icon GSE28355
Inactivation of BCL11A reactivates silenced human HbF in adult mice
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing.

Sample Metadata Fields

Sex, Specimen part

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accession-icon GSE28333
Expression data from BCL11A-null and wild-type bone marrow erythroid pregenitors
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

BCL11A is a critical mediator of hemoglobin switching and gamma-globin silencing. In this study, we showed the BCL11A is required in vivo for developmental silencing of gamma-globin genes in adult animals.

Publication Title

Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing.

Sample Metadata Fields

Sex, Specimen part

View Samples
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