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GSE75469
Homo sapiens
6 Downloadable Samples
Illumina HiSeq 2500
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
iCLIP identifies novel roles for SAFB1 in regulating RNA processing and neuronal function.
Sample Metadata Fields
Specimen part, Disease, Cell line
View Samples- Homo sapiens
- 9 Downloadable Samples
Illumina HumanHT-12 V4.0 expression beadchip
Description
IKB Kinase beta (IKKB), a key component of the NFKB signalling pathway plays an important role in inflammation and cancer. Here we describe a previously unknown role of the IKK/FoxO3a axis in bone metastasis. We found that IKK was highly expressed in invasive human breast tumours and that levels of expression were elevated in bone metastasis. Overexpression of IKK in parental and bone-tropic human breast cancer cell-lines increased tumour volume, worsened cachexia, promoted osteolysis and increased mortality in adult mice whereas pharmacological inhibition and knockdown of IKK were inhibitory. Inhibition of IKK in breast cancer cell lines and bone cells stimulated bone formation and reduced tumour growth by a mechanism that was mediated in part, by cytoplasmic sequestering of FoxO3a independently of NFKB inhibition. We conclude that IK contributes significantly to the regulation of tumour growth and osteolysis in breast cancer by NFKB dependent and independent mechanisms.
Publication Title
Regulation of breast cancer induced bone disease by cancer-specific IKKβ.
Sample Metadata Fields
Cell line
View Samples- Homo sapiens
- 6 Downloadable Samples
Illumina HiSeq 2500
Description
Comparison of control vs SAFB1 knockdown
Publication Title
iCLIP identifies novel roles for SAFB1 in regulating RNA processing and neuronal function.
Sample Metadata Fields
Disease, Cell line
View Samples