The sRNA profiles of the leaf and the root of 20-day-old plants were sequenced and the impacts of high energy status on sRNA expression were analyzed Overall design: 8 samples consisting of wild type, overexpressed line 7 and 21, and AtPAP2-mutant.
Global small RNA analysis in fast-growing Arabidopsis thaliana with elevated concentrations of ATP and sugars.
Subject
View SamplesA mouse model for human small cell lung carcinoma (SCLC) has been developed based on evidence in human tumors that the tumor suppressor functions of RB and p53 are defective in more than 90% of SCLC cases. We also developed another mouse model also combines loss of p130 (Rbl2), an RB-related gene, with deletion of RB and p53. These two mouse tumors were shown to closely resemble human SCLC.
Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma.
Specimen part
View SamplesWe report a new unsupervised clustering tool for single cell RNA-seq data called SC3. We show that biologically relevant information can be obtained from preneoplastic cells of patients with myeloprolifertive disease. Overall design: examination of three different patients with myeloproloferative disease
SC3: consensus clustering of single-cell RNA-seq data.
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