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E-BAIR-7
Mus musculus
56 Downloadable Samples
Affymetrix Mouse Expression 430B Array (moe430b), Affymetrix Mouse Expression 430A Array (moe430a)
Description
The basic design of the experiment is as described in Fryer et al.(2000)Diabetes 49:1978, and is similar to proto-BAIR (EXP_BAIR_0603_02). H-2Kb muscle cells were treated with metformin (2mM) or insulin (100nM) for 0, 2 or 12 hours.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part, Cell line, Compound, Time
View Samples- Mus musculus
- 32 Downloadable Samples
- Affymetrix Mouse Expression 430B Array (moe430b), Affymetrix Mouse Expression 430A Array (moe430a)
Description
Mice which lack IRS-2, develop insulin resistance. Comparison between liver tissue from 5 weeks old IRS-2 KO mice and wild type.
Publication Title
Gene expression analysis of liver tissue in five week old Insulin Receptor Substrate-2 (IRS-2) knock out mice.
Sample Metadata Fields
Age, Specimen part
View Samples- Mus musculus
- 28 Downloadable Samples
- Affymetrix Mouse Expression 430B Array (moe430b), Affymetrix Mouse Expression 430A Array (moe430a)
Description
Mice which lack IRS-2, develop insulin resistance. Comparison between muscle tissue from 5 week old IRS-2 KO mice and wild type.
Publication Title
Gene expression analysis of muscle tissue in five week old Insulin Receptor Substrate-2 (IRS-2) KO mice.
Sample Metadata Fields
Age, Specimen part
View Samples- Mus musculus
- 22 Downloadable Samples
- Affymetrix Mouse Expression 430B Array (moe430b), Affymetrix Mouse Expression 430A Array (moe430a)
Description
Mice which lack IRS-2, develop insulin resistance. Comparison between muscle tissue from 8 week IRS2-KO and wild type mice.
Publication Title
Gene expression analysis of muscle tissue in eight week old Insulin Receptor Substrate-2 (IRS-2) knock-out mice.
Sample Metadata Fields
Age, Specimen part
View Samples- Mus musculus
- 22 Downloadable Samples
- Affymetrix Mouse Expression 430B Array (moe430b), Affymetrix Mouse Expression 430A Array (moe430a)
Description
Mice which lack IRS-2, develop insulin resistance. Comparison between liver tissue from 8 week old IRS-2 KO and wild type mice.
Publication Title
No associated publication
Sample Metadata Fields
Age, Specimen part
View Samples- Mus musculus
- 22 Downloadable Samples
- Affymetrix Mouse Expression 430B Array (moe430b), Affymetrix Mouse Expression 430A Array (moe430a)
Description
Mice which lack IRS-2, develop insulin resistance. Comparison between white adipose tissue from 8 week old IRS-2 KO and wild type mice. Processed data is not included for this experiment and therefore these data are not MIAME compliant
Publication Title
Gene expression analysis of white adipose tissue in eight week old Insulin Receptor Substrate-2 (IRS-2) knock out mice.
Sample Metadata Fields
Age, Specimen part
View Samples- Homo sapiens
- 93 Downloadable Samples
- Affymetrix Human Gene 1.1 ST Array (hugene11st)
Description
In this experiment we catalogue transcriptional changes accompanying COPD in the quadriceps. We measure global gene transcription in the quadriceps using Affymetrix HuGene 1.1 ST arrays in an unselected cohort of 79 stable COPD patients in secondary care and 16 healthy age-and gender-matched controls.
Publication Title
COPD is accompanied by co-ordinated transcriptional perturbation in the quadriceps affecting the mitochondria and extracellular matrix.
Sample Metadata Fields
Disease, Disease stage
View Samples- Homo sapiens
- 84 Downloadable Samples
- Affymetrix Human Transcriptome Array 2.0 (hta20)
Description
We have previously identified hundreds of human islet lncRNAs. Here we functionally characterise 12 such lncRNAs in EndoC-betaH1 cells through loss of function studies.
Publication Title
Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks.
Sample Metadata Fields
Cell line
View Samples- Homo sapiens
- 37 Downloadable Samples
- Affymetrix Human Gene 1.1 ST Array (hugene11st)
Description
Asthma is characterized by intermittent inflammation of the airways, airflow limitation and wheeze. The ORMDL3 locus on chromosome 17q21 confers the major genetic susceptibility to childhood asthma. Although sphingolipids are important in immune signalling, the mechanisms of action of ORMDL3 on airway inflammation are incompletely understood.
Publication Title
No associated publication
Sample Metadata Fields
Cell line, Treatment
View Samples- Mus musculus
- 12 Downloadable Samples
- Affymetrix Mouse Gene 1.0 ST Array (mogene10st)
Description
E4bp4 is essential for the development of natural killer (NK) cells. We sought to identify downstream targets of E4bp4 by comparing mRNA expression in wild type vs. E4bp4 knockout
Publication Title
The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.
Sample Metadata Fields
Specimen part
View Samples