This SuperSeries is composed of the SubSeries listed below.
No associated publication
Specimen part
View SamplesGene expression analysis in CD4+ T cells extracted from allergen-challenged PBMCs, isolated from discordant MZ twins with IAR
No associated publication
Specimen part
View SamplesGene expression analysis in CD4+ T cells extracted from PBMCs, isolated from discordant MZ twins with IAR during season
No associated publication
Specimen part
View SamplesSperms being foreign to the female are to be promptly eliminated by the female local immune defense. However, avoiding the local immune defense sperm can be stored for lenthy period in the oviductal sperm reservoir. It is currently unknown whether oviductal sperm reservoirs changes their gene expression to tolerate the spermatozoa after mating or sperm free seminal plasma infusion. Therefore this was tested using Swedish Landrace pigs in this study using cDNA microarray.
No associated publication
Treatment
View SamplesGlobal gene expression analysis was performed to investigate the changes of the fibroblast phenotype after four-week inductions toward adipocytic, osteoblastic and chondrocytic lineages. Human cells.
Interpreted gene expression of human dermal fibroblasts after adipo-, chondro- and osteogenic phenotype shifts.
Specimen part
View SamplesExpression profiles of ZR751 breast cancer cells after downregulation of S6K1, S6K2 and S6K1+S6K2.
No associated publication
Sex, Cell line
View SamplesThe aim of the study was to investigate the apoptotic process in psoriatic keratinocytes. UV radiation was used as apoptosis stimuli. Restults provide insights into the role of UV radiation and apoptosis induction on cultured psoriatic keratinocytes compared to healthy controls.
No associated publication
Specimen part
View SamplesWT mice and mPGES-1 KO mice were treated with 120 mikrogram/kg LPS and sacrificed 5 h later.
No associated publication
Specimen part
View Samplesusing peripheral blood monocytes to identify marker genes for an extensively grown coronary collateral circulation.
Non-invasive gene-expression-based detection of well-developed collateral function in individuals with and without coronary artery disease.
Sex, Age
View SamplesSpecific microRNA (miRNA) signatures have been associated with different cytogenetic subtypes in acute leukemias. This finding prompted us to investigate potential associations between genetic abnormalities in multiple myeloma (MM) and singular miRNA expression profiles. Moreover, global gene expression profiling was also analyzed to find correlated miRNA-gene expression and select miRNA target genes that show such correlation. For this purpose, we analyzed the expression level of 365 miRNAs and the gene expression profiling in sixty newly diagnosed MM patients, selected to represent the most relevant recurrent genetic abnormalities. Supervised analysis showed significantly deregulated miRNAs in the different cytogenetic subtypes as compared to normal PC. Interestingly, miR-1 and miR-133a clustered on the same chromosomal loci, were specifically overexpressed in the cases with t(14;16). The analysis of the relationship between miRNA expression and their respective target genes showed a conserved inverse correlation between several miRNAs deregulated in MM cells and CCND2 expression level. These results illustrate, for the first time, that miRNA expression pattern in MM is associated with genetic abnormalities, and that the correlation of the expression profile of miRNA and their putative mRNA targets is useful to find statistically significant protein-coding genes in MM pathogenesis associated to changes in specific miRNAs.
Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling.
Specimen part, Disease
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