Ly6A/Sca-1 Fbxl10 Tg mice develop myeloid and B-cell leukemia with complete penetrance. (Ueda et al.,Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2, PMID 25872778)
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View SamplesAn activating mutation of ALK, ALK R1275Q was idenftified in neuroblastoma. ALK R1275Q knock-in/MYCN transgenic mice developed invasive and metastatic neuroblastoma with complete penetrance, coupled with decreased extracellular matrix/basement membrane components.
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View SamplesAn Immrtalized mouse embryonic fibroblast cell line (iMEF) was transduced with shRNA expression vectors and subjected for RNA-seq anaysis. Taf1c was knocked down by two different shRNAs. Enl and Mll were knocked down by single shRNA. RNAs were reverse-transcribed and subjected to deep sequencing along with the vector control sample (pLKO.1)
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Specimen part, Cell line
View SamplesTranscriptome analysis of hematopoietic stem cells [HSC (LSK)] (Eed cKO (flox/+ ERT2Cre+) vs control (flox/+ ERT2Cre-), 1 month post-tamoxifen injection, from 7 males and 4 females for each group
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Specimen part
View SamplesTranscriptome analysis of Hematopoietic stem cells [HSC (LSK)] (Ctrl (flox/flox, MxCre-) vs cKI (Q367P)(flox/flox, MxCre+), 3 months post pIpC injection
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Specimen part
View SamplesTranscriptome analysis of hematopoietic stem cells [HSC (LSK)] (Eed cKO (flox/flox ERT2Cre+) vs control (flox/flox ERT2Cre-). Mice were injected with tamoxifen for five consecutive days and then sacrificed two days after the final injection.
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Specimen part
View SamplesTranscriptome analysis of hematopoietic stem cells [HSC (LSK; Lin-, c-Kit+, Sca-1+ bone marrow cells)] (Eed I363M/+ vs Eed +/+) (males, 11-14 weeks of age)
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Sex, Cell line
View SamplesComprehensive identification and characterization of the WT mouse bonemarrow LSK transcriptome were attempted. We used RNA-seq.
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View SamplesComprehensive identification and characterization of the Titan hetero mouse bonemarrow LSK transcriptome were attempted. We used RNA-seq.
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View SamplesComprehensive identification and characterization of the Titan homo mouse bonemarrow LSK transcriptome were attempted. We used RNA-seq.
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