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SRP181726
Homo sapiens
1 Downloadable Sample
Illumina HiSeq 2000
Description
Former studies demonstrated that the cembranoid type diterpenes in tobacco has a good antimicrobial, antitumor and neuroprotective activity. Hepatocellular carcinoma has been the world's second largest malignant tumor in recent years. In this study, we isolated cembranoid type diterpenes from tobancco and detected its antitumor activity on hepatoma cell lines, a-2, 7, 11-cyprotermine-4, 6-diol (a-CBD) was used to investigate its antitumor activity on HepG2 cells in vitro.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part
View Samples- Homo sapiens
- 1 Downloadable Sample
- Illumina HiSeq 2000
Description
Former studies demonstrated that the cembranoid type diterpenes in tobacco has a good antimicrobial, antitumor and neuroprotective activity. Hepatocellular carcinoma has been the world's second largest malignant tumor in recent years. In this study, we isolated cembranoid type diterpenes from tobancco and detected its antitumor activity on hepatoma cell lines, a-2, 7, 11-cyprotermine-4, 6-diol (a-CBD) was used to investigate its antitumor activity on HepG2 cells in vitro.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part
View Samples- Homo sapiens
- 1 Downloadable Sample
- Illumina HiSeq 2000
Description
Former studies demonstrated that the cembranoid type diterpenes in tobacco has a good antimicrobial, antitumor and neuroprotective activity. Hepatocellular carcinoma has been the world's second largest malignant tumor in recent years. In this study, we isolated cembranoid type diterpenes from tobancco and detected its antitumor activity on hepatoma cell lines, a-2, 7, 11-cyprotermine-4, 6-diol (a-CBD) was used to investigate its antitumor activity on HepG2 cells in vitro.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part
View Samples- Homo sapiens
- 1 Downloadable Sample
- Illumina HiSeq 2000
Description
Former studies demonstrated that the cembranoid type diterpenes in tobacco has a good antimicrobial, antitumor and neuroprotective activity. Hepatocellular carcinoma has been the world's second largest malignant tumor in recent years. In this study, we isolated cembranoid type diterpenes from tobancco and detected its antitumor activity on hepatoma cell lines, a-2, 7, 11-cyprotermine-4, 6-diol (a-CBD) was used to investigate its antitumor activity on HepG2 cells in vitro.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part
View Samples- Homo sapiens
- 1 Downloadable Sample
- Illumina HiSeq 2000
Description
Former studies demonstrated that the cembranoid type diterpenes in tobacco has a good antimicrobial, antitumor and neuroprotective activity. Hepatocellular carcinoma has been the world's second largest malignant tumor in recent years. In this study, we isolated cembranoid type diterpenes from tobancco and detected its antitumor activity on hepatoma cell lines, a-2, 7, 11-cyprotermine-4, 6-diol (a-CBD) was used to investigate its antitumor activity on HepG2 cells in vitro.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part
View Samples- Homo sapiens
- 1 Downloadable Sample
- Illumina HiSeq 2000
Description
Former studies demonstrated that the cembranoid type diterpenes in tobacco has a good antimicrobial, antitumor and neuroprotective activity. Hepatocellular carcinoma has been the world's second largest malignant tumor in recent years. In this study, we isolated cembranoid type diterpenes from tobancco and detected its antitumor activity on hepatoma cell lines, a-2, 7, 11-cyprotermine-4, 6-diol (a-CBD) was used to investigate its antitumor activity on HepG2 cells in vitro.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part
View Samples- Arabidopsis thaliana
- 12 Downloadable Samples
Affymetrix Arabidopsis ATH1 Genome Array (ath1121501)
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
RDM4 modulates cold stress resistance in Arabidopsis partially through the CBF-mediated pathway.
Sample Metadata Fields
Specimen part
View Samples- Triticum turgidum subsp. durum, Triticum carthlicum, Triticum aestivum, Aegilops tauschii
- 12 Downloadable Samples
- Affymetrix Wheat Genome Array (wheat)
Description
Alteration in gene expression accompanying initial stages of allopolyploidy is a prominent feature in plants, but its spectrum and model are highly idiosyncratic. We used multi-colour GISH to identify individuals from two nascent allohexaploid wheat lines between Triticum turgidum and Aegilops tauschii, which had a transgenerationally stable chromosomal constitution mimicking that of common wheat. We performed genomewide analysis of gene expression for these plants along with their parental species using the Affymetrix GeneChip Wheat Genome-Array. Comparison with parental species coupled with inclusion of empirical mid-parent values (MPVs) revealed two patterns of alteration in gene expression in the allohexaploid lines: parental dominance expression and nonadditive expression. Genes involved in each altered pattern could be classified into three distinct groups, stochastic, heritable and persistent, based on their transgenerational heritability and inter-line conservation. Whereas both altered patterns of gene expression showed a propensity of inheritance, identity of the involved genes is stochastic, consistent with the involvement of diverse Gene Ontology (GO) terms. Nonetheless, those genes showing nonadditive expression exhibited a significant enrichment for vesicle-function. Our results suggest global alteration in gene expression conditioned by nascent allopolyploidy likely play functional roles in stabilization and establishment of the newly formed plants, and consequential to evolution.
Publication Title
No associated publication
Sample Metadata Fields
Specimen part
View Samples- Mus musculus
- 12 Downloadable Samples
- Affymetrix Mouse Genome 430 2.0 Array (mouse4302)
Description
Haploid pluripotent stem cells, such as haploid embryonic stem cells (haESCs), facilitate the genetic study of recessive traits. In vitro, fish haESCs maintain haploidy in both undifferentiated and differentiated states, but whether mammalian haESCs can preserve pluripotency in the haploid state has not been tested. Here, we report that mouse haESCs can differentiate in vitro into haploid epiblast stem cells (haEpiSCs), which maintain an intact haploid genome, unlimited self-renewal potential, and durable pluripotency to differentiate into various tissues in vitro and in vivo. Mechanistically, the maintenance of self-renewal potential depends on the Activin/bFGF pathway. We further show that haEpiSCs can differentiate in vitro into haploid progenitor-like cells.
Publication Title
Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro.
Sample Metadata Fields
Specimen part
View Samples- Arabidopsis thaliana
- 12 Downloadable Samples
- Affymetrix Arabidopsis ATH1 Genome Array (ath1121501)
Description
In plants, CCCH zinc finger proteins involved in secondary wall formation and anther development are poorly understood. We have functionally identified two homologous genes C3H14 and C3H15 and found that the two genes differentially regulate secondary wall formation and anther development. C3H14 contributes more to secondary wall thickening, whereas, C3H15 is more important for anther development.
Publication Title
Arabidopsis C3H14 and C3H15 have overlapping roles in the regulation of secondary wall thickening and anther development.
Sample Metadata Fields
Specimen part
View Samples