Growth of the drosophila eye imaginal discs is controlled by the activation of Notch in the dorsal-ventral boundary. Overexpression in the eye disc of the Notch ligand Delta together with lola and pipsqueak from the GS(2)88A8 line induces tumoral growth. We used microarray to analyze the expression profile of tumoral discs.
Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation.
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View SamplesTo identify genes expressed in specific developing thalamic nuclei during embryonic stages, a genetic dual labelling strategy was established to mark and isolate the cells. Transcription profiles were determined for the principal sensory thalamic populations by genome-wide analysis.
Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes.
Specimen part
View SamplesMisguided visual thalamic axons leads to changes in gene expression in visual thalamic neurons.
Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes.
Specimen part
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition.
Sex, Age, Specimen part, Treatment
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Genomic landscape of transcriptional and epigenetic dysregulation in early onset polyglutamine disease.
Sex, Age, Specimen part
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Loss of neuronal 3D chromatin organization causes transcriptional and behavioural deficits related to serotonergic dysfunction.
Sex, Specimen part
View SamplesTo investigate downstream targets of PRRX1, we used MDA-MB-231 (MDA231) breast cancer cells which express low level of PRRX1 to generate a stable cell line where human PRRX1 was ectopically overexpressed
A gene regulatory network to control EMT programs in development and disease.
Specimen part
View SamplesSubstantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease. However, ventral tegmental area (VTA), a region adjacent to SNpc, is less affected in PD. Until now, molecular mechanisms behind VTA aging have not been fully investigated using high throughput techniques.
Age-mediated transcriptomic changes in adult mouse substantia nigra.
Specimen part
View SamplesSubstantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease. Until now, molecular mechanisms behind SNpc aging have not been fully investigated using high throughput techniques.
Age-mediated transcriptomic changes in adult mouse substantia nigra.
Specimen part
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Age-mediated transcriptomic changes in adult mouse substantia nigra.
Specimen part
View Samples